R&D Performances
Leading the way in developing state-of-the-art therapeutics
Core research areas
New Drug

Discovery and industrialization of innovative drugs targeting severe refractory diseases

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Category

Discovery of therapeutic targets, Discovery of drug candidates

Achievements

Independently operated “Center for Drug Discovery Support” that mediates basic and clinical studies.

Establishment of the core-labs for applied antibodies development, drug metabolism and pharmacokinetics, and medical and pharmaceutical chemistry

Target diseases

Cancer, inflammatory/immunologic diseases, severe geriatric diseases, endocrinologic diseases, nuclear medicine

Inventions

Candidate molecules (e.g., DPP-4 inhibitor) for prevention or treatment of valvular calcification

Patents

Compositions comprising α-lipoic acid and N-acetylcysteine for preventing or treating obesity.

Composition for predicting risk of thiopurine-induced leukopenia, containing single nucleotide polymorphism marker within NUDT15 gene.

Pharmaceutical composition for prevention or treatment of metabolic disease, comprising bacteroides acidifaciens as effective ingredient for predicting risk of thiopurine-induced leukopenia, containing single nucleotide polymorphism marker within NUDT15 gene.

Method for separating nucleic acids from FEPE tissue.

Pharmaceutical composition for suppressing appetite, containing N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine) (TNP) or pharmaceutically acceptable salt thereof as active ingredient.

Cell Therapy

Stem cell-based therapeutics for refractory diseases and patient-specific drugs

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Category

Cell therapy, Cell-based technology

Achievements

Advancement of core technology for stem cell-based therapeutics and establishment of basis for clinical trials on stem cell-based therapeutics

Development of next-generation cell therapy and expansion for its indication

Target diseases

Pulmonology, lung cancer, kidney/urology, endocrinology, gastroenterology, auto-immune

Inventions

Pharmaceutical composition for treatment of prevention of ketamine-induced cystitis, containing mesenchymal stem cells.

Composition for inducing the differentiation for induced pluripotent stem cell.

Therapeutic composition for improvement, prevention, or treatment of skin diseases, containing induced pluripotent stem cell-derived mesenchymal stem cells and exosomes derived from thereof.

Functionally enhanced stem cells and their medical usage

Composition for immune improvement or enhancement of anti-cancer activity, comprising MAL-expressing stem cell-like memory T cells.

Patents

Medical Device

Development of fusion precision treatment and automated medical devices based on clinical needs

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Category

Surgery and therapy, Biometrics / imaging diagnosis

Achievements

Clinical prototype of assistive robot for interventions

Start-up business in 3D printed medical devices and their clinical application

Clinical application of cell sheets and development of the core technology for bioprinting

Core technology for microfluidics chip-based precision treatment and diagnostics

Target diseases

Cardiovascular, Gastroenterology, Neurology, Opthalmology, Otorhinolaryngology, Musculoskeletal, Radiology, Nuclear medicine

Inventions

Brain disease diagnosis service apparatus and brain disease diagnosis service method

Method for distinguishing pulmonary artery and pulmonary vein, and method for quantifying blood vessels using same

Noninvasive atrial activity estimation system and method

Mucosal dose control radiotherapy apparatus using magnetic fields

Method for generating insertion trajectory of surgical needle

Patents

Method for estimating onset time of infarct region based on brain image

Hybrid stent

Method for testing NK cell activity using synergistic activity of receptor, and method for diagnosing disease associated with NK cell activity using same.

Big Data

Development of an infrastructure for application of clinical big data and related models for clinical application

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Category

Big data

Achievements

Establishment of a platform for radiologic/clinic/genomic big data and its clinical application

Target diseases

Administration of the medical big data application platform business (Korea Data and Software-driven Hospital Consortium, Ministry of Science and ICT, 2018)

Genome information system ? ABLE interlinked database and establishment of an OHDSI-based CDM system

Establishment of an open innovation research infracstructure

Inventions

Method and device for predicting chronic lung disease by using fractal dimension values

Method, device, and program for predicting changes in brain disease through machine learning

Supporting system and method for thoracic medical image analysis

Method and system for patient identification

Device and method for image processing

Patents